abstract：OBJECTIVE:Constipation is one of the most common gastrointestinal complications suspected to degrade the quality of life in diabetic patients. Mosapride citrate is a novel selective 5-HT4 receptor agonist, which enhances gastric emptying and motility in the upper gastrointestinal tract facilitating acetylcholine releas...

journal_title：Diabetes research and clinical practice

authors： Ueno N,Inui A,Satoh Y

更新日期：2010-01-01 00:00:00

abstract：:The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-gamma as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. In this experimental study, serum sample...

journal_title：Diabetes research and clinical practice

authors： Arababadi MK,Nosratabadi R,Hassanshahi G,Yaghini N,Pooladvand V,Shamsizadeh A,Hakimi H,Derakhshan R

更新日期：2010-01-01 00:00:00

abstract：:The predictive value of hemoglobin A1c (HbA1c) in comparison to fasting plasma glucose (FPG) is evaluated for 5-year incident diabetes (DM), as HbA1c may be more practical than FPG in the screening for DM in the future. Of 1189 non-DM subjects aged 35-89 years old from the Funagata Study, 57 subjects (4.8%) had develo...

journal_title：Diabetes research and clinical practice

authors： Nakagami T,Tajima N,Oizumi T,Karasawa S,Wada K,Kameda W,Susa S,Kato T,Daimon M

更新日期：2010-01-01 00:00:00

abstract：:The increasing proportions of older persons accounting for global populations, and the implications for increasing rates of chronic diseases such as type 2 diabetes mellitus, continue to be a cause of concern for clinicians. Considering that older persons are a very heterogeneous group of individuals, the management o...

journal_title：Diabetes research and clinical practice

authors： Abbatecola AM,Paolisso G

更新日期：2009-12-01 00:00:00

abstract：AIMS:To test whether the genetic variant CCR5Delta32 in the CC-chemokine receptor 5, which is known to lead to CCR5 deficiency, is associated with mortality in type 2 diabetes patients. METHODS:We examined the effect of presence or absence of the CCR5Delta32 on overall and cardiovascular mortality risk in the Zwolle O...

journal_title：Diabetes research and clinical practice

authors： Muntinghe FL,Gross S,Bakker SJ,Landman GW,van der Harst P,Bilo HJ,Navis G,Zuurman MW

更新日期：2009-11-01 00:00:00

abstract：:We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2-4-fold significant increase (p<0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased Mt...

journal_title：Diabetes research and clinical practice

authors： Malik AN,Shahni R,Iqbal MM

更新日期：2009-11-01 00:00:00

abstract：:We used data of 1652 male adults aged 20-60 years from KNHANES III. Short sleep duration was significantly associated with an increased prevalence of type 2 diabetes in Korean male adults without abdominal obesity (OR in sleep duration of

journal_title：Diabetes research and clinical practice

authors： Kim J,Kim HM,Kim KM,Kim DJ

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:To determine risk factors in clinically significant macular edema (CSME) and if increased CSME in minorities is due to ethnicity or other factors in the Veterans Affairs Diabetes Trial (VADT). METHODS:CSME prevalence based on 7-field stereo fundus photographs in 1268 patients with type 2 diabetes was related...

journal_title：Diabetes research and clinical practice

authors： Emanuele N,Moritz T,Klein R,Davis MD,Glander K,Khanna A,Thottapurathu L,Bahn G,Duckworth W,Abraira C,Veterans Affairs Diabetes Trial Study Group.

更新日期：2009-11-01 00:00:00

abstract：AIM:We previously identified the transcription factor activating enhancer-binding protein-2beta (AP-2beta) gene as a new candidate for conferring susceptibility to type 2 diabetes. To ascertain the possible involvement of AP-2beta in the pathogenesis of type 2 diabetes we examined the effects of AP-2beta on glucose-ind...

journal_title：Diabetes research and clinical practice

authors： Tsukada S,Kobayashi MA,Omori S,Unoki H,Maeda S

更新日期：2009-09-01 00:00:00

abstract：AIMS:The circadian rhythm and immune system are thought to be associated with the pathological state of diabetes. The aim of this study was to examine the correlation of circadian rhythm disturbance including sleep disturbance with the immune state in patients with type 2 diabetes compared to healthy controls. METHODS...

journal_title：Diabetes research and clinical practice

authors： Tsujimura T,Matsuo Y,Keyaki T,Sakurada K,Imanishi J

更新日期：2009-09-01 00:00:00

abstract：:A 31-year-old woman, having a type-1 diabetes and an insulin allergy, was successfully treated with a subcutaneous antihistamine injection to the next continuous subcutaneous insulin infusion site. ...

journal_title：Diabetes research and clinical practice

authors： Imakado S,Hamada K,Atsumi Y

更新日期：2009-09-01 00:00:00

abstract：AIMS:The aim of the present study was to determine the prevalence of abnormal glucose tolerance and the metabolic syndrome in a cohort of previously gestational diabetic (GDM) women 4 years after delivery. METHODS:Sixty-eight prior GDM and a control group of 39 women with normal glucose tolerance during pregnancy were...

journal_title：Diabetes research and clinical practice

authors： Madarász E,Tamás G,Tabák AG,Kerényi Z

更新日期：2009-08-01 00:00:00

abstract：AIMS:Gestational diabetes mellitus (GDM) is associated with adverse obstetrical outcomes and postpartum pre-diabetes/diabetes. As the American Diabetes Association (ADA) criteria for GDM may capture obstetrical risk better than the National Diabetes Data Group (NDDG) criteria, we compared these criteria in their detect...

journal_title：Diabetes research and clinical practice

authors： Retnakaran R,Qi Y,Sermer M,Connelly PW,Zinman B,Hanley AJ

更新日期：2009-07-01 00:00:00

abstract：AIMS:To determine the appropriate cutoff value of waist circumference associated with cardiometabolic risk factors in Koreans. METHODS:Clinical and laboratory data on 31,076 Korean adults (age 20-89 years, 40% women) were recorded at regular health check-ups. Receiver operating characteristic curves were used to deter...

journal_title：Diabetes research and clinical practice

authors： Kim HK,Kim CH,Park JY,Lee KU

更新日期：2009-07-01 00:00:00

abstract：AIMS:To evaluate the incidence of impaired glucose tolerance (IGT), impaired fasting glucose (IFG) and diabetes in 318 Caucasian women with gestational diabetes (GDM) at 6 weeks postpartum. METHODS:All women had 75g OGTT and the following data were collected: age, height, weight, results of the challenge 50g and diagn...

journal_title：Diabetes research and clinical practice

authors： Ogonowski J,Miazgowski T

更新日期：2009-06-01 00:00:00

abstract：AIMS:To investigate alterations of insulin resistance (IR), chronic inflammation and urine albumin-to-creatinine ratio (ACR) in Chinese community-based prediabetic population. MATERIALS AND METHODS:252 prediabetics [prediabetes (PD), including impaired fasting glucose (IFG), 91; impaired glucose tolerance (IGT), 123; ...

journal_title：Diabetes research and clinical practice

authors： Lü Q,Tong N,Liu Y,Li N,Tang X,Zhao J,Cao H,Li D,Gou L,Zhang Y,Wan J,Jiang L

更新日期：2009-06-01 00:00:00

abstract：:The patient was a 56-year-old man with type 2 diabetes and insulin allergy. He was administered glargine, which did not produce any allergic reactions, except for a small non-pruritic wheal. Thereafter, other insulin preparation could be administered. We consider this the first case of successful insulin desensitizati...

journal_title：Diabetes research and clinical practice

authors： Hara M,Izumida Y,Sato N,Ohashi K,Osuga J,Tobe K,Tsukamoto K,Kadowaki T

更新日期：2009-06-01 00:00:00

abstract：AIM:The aim of this study was to assess the vaspin and adiponectin concentrations on markers of insulin sensitivity and obesity in pubertal obese children and adolescents. MATERIAL AND METHODS:Plasma vaspin and adiponectin level and its relationships with body mass index standard deviation score (BMI-SDS), insulin sen...

journal_title：Diabetes research and clinical practice

authors： Suleymanoglu S,Tascilar E,Pirgon O,Tapan S,Meral C,Abaci A

更新日期：2009-06-01 00:00:00

abstract：UNLABELLED:The endothelium plays an integral role in the regulation of vascular tone, platelet activity, leukocyte adhesion, and thrombosis and is intimately involved in the development of atherosclerosis. Endothelial dysfunction has been observed in patients with established coronary artery disease or coronary risk fa...

journal_title：Diabetes research and clinical practice

authors： Grover-Páez F,Zavalza-Gómez AB

更新日期：2009-04-01 00:00:00

abstract：AIMS:To investigate whether increased risk of severe hypoglycaemia in early pregnancy is related to pregnancy-induced changes in renin-angiotensin system (RAS) activity in women with type 1 diabetes (T1DM). METHODS:Severe hypoglycaemic events the year preceding pregnancy were recorded retrospectively in 107 consecutiv...

journal_title：Diabetes research and clinical practice

authors： Nielsen LR,Pedersen-Bjergaard U,Thorsteinsson B,Boomsma F,Damm P,Mathiesen ER

更新日期：2009-04-01 00:00:00

abstract：:There is scant knowledge on the changes in renal histological findings in type 1 diabetic patients those initially had nephrotic proteinuria and decreased renal function and later had complete remission of diabetic nephropathy by multifactorial treatment (MFT). A 44-year-old Japanese type 1 diabetic woman (duration of...

journal_title：Diabetes research and clinical practice

authors： Haraguchi K,Hara S,Ubara Y,Tanaka S,Nukui I,Shimura H,Ohashi K,Kobayashi T

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:Combination of drugs with different mechanisms of action helps in achieving synergistic analgesic effect in neuropathic pain. Keeping this point in view, the effect and safety aspects of sodium valproate and GTN were assessed alone as well as in combination in this study. DESIGN:Prospective double-blind ran...

journal_title：Diabetes research and clinical practice

authors： Agrawal RP,Goswami J,Jain S,Kochar DK

更新日期：2009-03-01 00:00:00

abstract：:To determine the status of diabetes care by general practitioners and diabetes specialists in Japan, we conducted a nation-wide cross-sectional survey. We asked 8112 clinics and hospitals randomly, from throughout Japan, to participate in this study and 721 facilities agreed. A total of 15,652 patients aged from 15 to...

journal_title：Diabetes research and clinical practice

authors： Arai K,Hirao K,Matsuba I,Takai M,Matoba K,Takeda H,Kanamori A,Yamauchi M,Mori H,Terauchi Y

更新日期：2009-03-01 00:00:00

abstract：:The role of post-prandial glucose on cardiovascular risk among Chinese adults without diabetes was investigated. In a median follow-up of 3.5 years on 16,590 participants, 95 cardiovascular deaths were found. The relative risk in the highest quintile post-prandial glucose was 1.61 (P for trend, 0.05) for cardiovascula...

journal_title：Diabetes research and clinical practice

authors： Chien KL,Lee BC,Lin HJ,Hsu HC,Chen MF

更新日期：2009-02-01 00:00:00

abstract：:Our previous finding has shown that a suggestive linkage existed in D20S196 in diabetic families with lowered BMI in eastern Chinese population. The aim of this study is to investigate whether variants in PCK1 gene, located in this region, was associated with type 2 diabetes in eastern China. Eleven SNPs were identifi...

journal_title：Diabetes research and clinical practice

authors： Dong Y,Zhang H,Wang X,Feng Q,Chen X,Su Q

更新日期：2009-02-01 00:00:00

abstract：:Hyperleptinemia, hypoadiponectinemia, and hyperresistinemia were found to be significantly higher with odds ratios (CI 95%) of 2.15, 2.05 and 3.05, respectively, among cigarette smokers with type 2 diabetes in Saudi Arabian population. Smoking cessation restored the adiponectin and leptin levels while having a modest ...

journal_title：Diabetes research and clinical practice

authors： Al-Daghri NM,Al-Attas OS,Hussain T,Sabico S,Bamakhramah A

更新日期：2009-02-01 00:00:00

abstract：:This review focuses on the burgeoning use of web-based systems allowing patient-initiated glucometer uploads to facilitate provider treatment intensification. Studies in type 1 diabetes tended to show equivalent HbA1c improvements in both intervention and control groups without statistically significant difference. In...

journal_title：Diabetes research and clinical practice

authors： Azar M,Gabbay R

更新日期：2009-01-01 00:00:00

abstract：AIM:Cardiovascular autonomic neuropathy (CAN) increases mortality of patients with type 1 diabetes (Type 1 DM). We set out to find out whether the presence of CAN in asymptomatic, normotensive Type 1 DM affects endothelial function (marker of atherogenesis) and left ventricle function (marker of cardiomyopathy). METHO...

journal_title：Diabetes research and clinical practice

authors： Lacigova S,Bartunek L,Cechurova D,Visek J,Gruberova J,Krcma M,Jankovec Z,Rusavy Z,Zourek M

更新日期：2009-01-01 00:00:00

abstract：:Self-monitoring of blood glucose (SMBG) in type 2 diabetic patients was compared across 14 countries. There was an unexpectedly high SMBG-use in non-insulin-treated patients. Reimbursement polices differed by country, region, insurance status, and patient income. More rigorous and systematic data collection is needed ...

journal_title：Diabetes research and clinical practice

authors： SMBG International Working Group.

更新日期：2008-12-01 00:00:00

abstract：AIMS:To investigate ethnic difference by focusing on fasting serum insulin (FSI) in inter-East Asian subjects with normal glucose tolerance (NGT) and impaired glucose regulation (IGR). METHODS:Data sources included MEDLINE and EMBASE between 2001 and 2007. We conducted a search for articles containing mean or geometri...

journal_title：Diabetes research and clinical practice

authors： Takeuchi M,Okamoto K,Takagi T,Ishii H

更新日期：2008-12-01 00:00:00

abstract：:Amid the rapidly rising number of people with diabetes worldwide, the prevalence of diabetic kidney disease (DKD) is expected to increase considerably despite available treatments. Consequently, novel therapeutic agents are urgently needed. Ruboxistaurin mesylate is a bisindolylmaleimide that specifically inhibits the...

journal_title：Diabetes research and clinical practice

authors： Tuttle KR

更新日期：2008-11-13 00:00:00

abstract：AIM:Data suggest that 2h hyperglycaemia during an OGTT is less predictive for cardiovascular disease of the glucose "spike" (the difference between the baseline glucose level and the "peak" hyperglycaemia during the test). METHODS:A euinsulinemic hyperglycaemic clamp at 10 and 15mmol/l glucose, with or without vitamin...

journal_title：Diabetes research and clinical practice

authors： Ceriello A,Esposito K,Piconi L,Ihnat M,Thorpe J,Testa R,Bonfigli AR,Giugliano D

更新日期：2008-11-01 00:00:00

abstract：:Circulating levels of osteoprotegerin (OPG) have been shown to be increased in patients with cardiovascular disorders and diabetes. The aim of this study was to determine serum OPG levels in women with previous gestational diabetes (GDM), and to investigate the relationship between OPG and carotid intima media thickne...

journal_title：Diabetes research and clinical practice

authors： Akinci B,Demir T,Celtik A,Baris M,Yener S,Ozcan MA,Yuksel F,Secil M,Yesil S

更新日期：2008-11-01 00:00:00

abstract：AIMS:To determine the relationships between cardiovascular autonomic neuropathy (CAN) and autonomic symptoms, clinical parameters and diabetic complications in type 2 diabetes (T2DM). METHODS:The results of autonomic symptoms, clinical parameters, diabetes complications and cardiovascular reflex (CVR) tests of 674 T2D...

journal_title：Diabetes research and clinical practice

authors： Chen HT,Lin HD,Won JG,Lee CH,Wu SC,Lin JD,Juan LY,Ho LT,Tang KT

更新日期：2008-11-01 00:00:00

abstract：:Non-specific aggression to endocrine alpha and beta cells as well as exocrine pancreas has been suggested in fulminant type 1 diabetes (FT1DM), while its effect on glucagon secretion and exocrine function is unknown. Here, we report a FT1DM case with exocrine pancreatic insufficiency and enhanced glucagon response to ...

journal_title：Diabetes research and clinical practice

authors： Yabe D,Kuroe A,Ohya M,Watanabe K,Kitatani N,Oku M,Kurose T,Seino Y

更新日期：2008-11-01 00:00:00

abstract：:To investigate the evolution and significance of Q waves in type 2 diabetes, we studied 36 patients of mean (+/-S.D.) age 69.9+/-7.1 years from the longitudinal observational Fremantle Diabetes Study (FDS). All had (i) neither history/symptoms of coronary heart disease (CHD) nor pathological Q waves at FDS recruitment...

journal_title：Diabetes research and clinical practice

authors： Kondola S,Davis WA,Dembo LG,Davis TM

更新日期：2008-10-01 00:00:00

abstract：AIMS:Central obesity, a prominent feature of metabolic syndrome (MetS), is commonly assessed by gender- and ethnicity-specific waist circumference (WC) cut-off values. Since 2006, the recommended WC cut-offs by the International Diabetes Federation (IDF) for Europeans are used in Iran because of limited data availabili...

journal_title：Diabetes research and clinical practice

authors： Esteghamati A,Ashraf H,Rashidi A,Meysamie A

更新日期：2008-10-01 00:00:00

abstract：:Using a database of patients with type 1 (n=1675) and type 2 (n=2259) diabetes diagnosed before the age of 30 years at the Diabetes Center, Tokyo Women's Medical University (TWMU), in which such Japanese patients have been registered at the time of first visit since the 1960s, we performed a hospital-based study over ...

journal_title：Diabetes research and clinical practice

authors： Uchigata Y,Otani T,Takaike H,Miura J,Osawa M,Tukahara S,Kasahara T,Iwamoto Y

更新日期：2008-10-01 00:00:00

abstract：AIMS:We investigated the relationship of urinary albumin excretion (UAE) to metabolic syndrome and type 2 diabetes in Asian. METHODS:A total of 446 subjects (187 without diabetes and 259 with type 2 diabetes) were enrolled in this study. The components of metabolic syndrome, high sensitivity C-reactive protein (hs-CRP...

journal_title：Diabetes research and clinical practice

authors： Lee IT,Huang CN,Lee WJ,Lee HS,Sheu WH

更新日期：2008-09-01 00:00:00

abstract：:This paper aims to underscore the importance of insulin intensification, while highlighting the clinical utility of modern premixes through intensification lessons, by utilising data from key clinical trials, and from the recently published large observational PRESENT Study. Insulin intensification is any change made ...

journal_title：Diabetes research and clinical practice

authors： Guler S,Vaz JA,Ligthelm R

更新日期：2008-09-01 00:00:00